NEWS

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ClinicalVariantR 0.99.0 (2026-07-08)

• Initial Bioconductor submission scaffold (x.99.y versioning).
• Interactive Shiny platform for ACMG/AMP germline variant classification from VEP / SnpEff / ANNOVAR-annotated VCFs.
• Three workflows: full clinical (Group A), automated rapid (Group B), and gene-panel (Group C).
• Streaming whole-VCF analysis with optional bcftools acceleration.
• Structured criterion-level evidence export and reproducibility metadata.
• Package entry points: ClinicalVariantR() / ClinicalVariantRApp() return a Shiny app object (user launches with shiny::runApp()).
• Vignettes: introduction (ClinicalVariantR.Rmd) and run/test guide (ClinicalVariantR-run-and-test.Rmd) covering app launch, sample data, UI checks, and CLI/unit tests.