Changes in version 0.99.0 (2026-07-08)                 

  - Initial Bioconductor submission scaffold (x.99.y versioning).
  - Interactive Shiny platform for ACMG/AMP germline variant
    classification from VEP / SnpEff / ANNOVAR-annotated VCFs.
  - Three workflows: full clinical (Group A), automated rapid (Group B),
    and gene-panel (Group C).
  - Streaming whole-VCF analysis with optional bcftools acceleration.
  - Structured criterion-level evidence export and reproducibility
    metadata.
  - Package entry points: ClinicalVariantR() / ClinicalVariantRApp()
    return a Shiny app object (user launches with shiny::runApp()).
  - Vignettes: introduction (ClinicalVariantR.Rmd) and run/test guide
    (ClinicalVariantR-run-and-test.Rmd) covering app launch, sample
    data, UI checks, and CLI/unit tests.