Package: MRCCC
Type: Package
Title: Bayesian Mendelian Randomization for Causal Cell-Cell
        Communication
Version: 0.99.4
Authors@R: c(
    person("Bitan", "Sarkar", email = "bitansarkar010899@gmail.com",
           role = c("aut", "cre"),
           comment = c(ORCID = "0009-0000-5178-5934")),
    person("Yang", "Ni", role = "aut",
           comment = c(ORCID = "0000-0003-0636-2363")))
Description: Implements MR-CCC, a Bayesian Mendelian randomization
        framework for inferring causal ligand-receptor signalling
        between cell types from population-scale single-cell expression
        and genotype data. For each ligand-receptor-pathway triplet,
        cis-eQTL genotypes instrument ligand expression in the sender
        cell type and receptor expression in the receiver cell type,
        and a working model with a ligand-by-receptor interaction is
        fitted to downstream pathway activity by a blocked Gibbs
        sampler. A spike-and-slab prior on the causal block yields a
        posterior inclusion probability that serves as the
        communication score, and the retained draws support credible
        intervals, sign probabilities, the receptor level at which the
        ligand effect reverses sign, and Bayesian false discovery rate
        control across many triplets.
License: MIT + file LICENSE
Encoding: UTF-8
Depends: R (>= 4.5.0)
Imports: Rcpp, SummarizedExperiment, ggplot2 (>= 3.4.0), stats,
        methods, withr (>= 2.5.0)
LinkingTo: Rcpp, RcppArmadillo
Suggests: testthat (>= 3.0.0), knitr, rmarkdown, BiocStyle
VignetteBuilder: knitr
biocViews: Software, StatisticalMethod, Bayesian, GeneExpression,
        SingleCell, Genetics, SystemsBiology, GeneRegulation
URL: https://github.com/bitansa/MRCCC
BugReports: https://github.com/bitansa/MRCCC/issues
Roxygen: list(markdown = TRUE)
Config/testthat/edition: 3
NeedsCompilation: yes
Config/roxygen2/version: 8.1.0
Config/pak/sysreqs: zlib1g-dev
Repository: https://biocstaging.r-universe.dev
Date/Publication: 2026-10-08 20:03:06 UTC
RemoteUrl: https://github.com/BiocStaging/MRCCC
RemoteRef: HEAD
RemoteSha: 8078793179259416e2e7643070057fadb472410b
Packaged: 2026-10-08 20:34:06 UTC; root
Author: Bitan Sarkar [aut, cre] (ORCID:
    <https://orcid.org/0009-0000-5178-5934>),
  Yang Ni [aut] (ORCID: <https://orcid.org/0000-0003-0636-2363>)
Maintainer: Bitan Sarkar <bitansarkar010899@gmail.com>