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# CITATION.cff file created with {cffr} R package
# See also: https://docs.ropensci.org/cffr/
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cff-version: 1.2.0
message: 'To cite package "MRCCC" in publications use:'
type: software
license: MIT
title: 'MRCCC: Bayesian Mendelian Randomization for Causal Cell-Cell Communication'
version: 0.99.4
doi: 10.48550/arXiv.2604.23917
identifiers:
- type: doi
  value: 10.32614/CRAN.package.MRCCC
abstract: Implements MR-CCC, a Bayesian Mendelian randomization framework for inferring
  causal ligand-receptor signalling between cell types from population-scale single-cell
  expression and genotype data. For each ligand-receptor-pathway triplet, cis-eQTL
  genotypes instrument ligand expression in the sender cell type and receptor expression
  in the receiver cell type, and a working model with a ligand-by-receptor interaction
  is fitted to downstream pathway activity by a blocked Gibbs sampler. A spike-and-slab
  prior on the causal block yields a posterior inclusion probability that serves as
  the communication score, and the retained draws support credible intervals, sign
  probabilities, the receptor level at which the ligand effect reverses sign, and
  Bayesian false discovery rate control across many triplets.
authors:
- family-names: Sarkar
  given-names: Bitan
  email: bitansarkar010899@gmail.com
  orcid: https://orcid.org/0009-0000-5178-5934
- family-names: Ni
  given-names: Yang
  orcid: https://orcid.org/0000-0003-0636-2363
preferred-citation:
  type: generic
  title: 'MR-CCC: Bayesian Mendelian Randomization for Causal Cell-Cell Communication'
  authors:
  - family-names: Sarkar
    given-names: Bitan
    email: bitansarkar010899@gmail.com
    orcid: https://orcid.org/0009-0000-5178-5934
  - family-names: Ni
    given-names: Yang
    orcid: https://orcid.org/0000-0003-0636-2363
  year: '2026'
  doi: 10.48550/arXiv.2604.23917
  url: https://arxiv.org/abs/2604.23917
repository: https://biocstaging.r-universe.dev
repository-code: https://github.com/bitansa/MRCCC
commit: 8078793179259416e2e7643070057fadb472410b
url: https://github.com/bitansa/MRCCC
date-released: '2026-10-08'
contact:
- family-names: Sarkar
  given-names: Bitan
  email: bitansarkar010899@gmail.com
  orcid: https://orcid.org/0009-0000-5178-5934