Package: MiCARA Title: Microbiome Confounder-Adjusted Robust Analysis Version: 0.99.2 Authors@R: person("Safa", "Bushnaq", , "19397747@brookes.ac.uk", role = c("aut", "cre"), comment = c(ORCID = "0009-0000-3723-5725")) Description: Provides a comprehensive framework for multi-cohort microbiome differential abundance and residual correlation analysis. It integrates confounder-adjusted linear models with centered log-ratio transformed taxonomic and functional pathway profiles. The package features robust preprocessing, automated covariate handling, multiple-testing correction, and quality control diagnostics for multi-omics data. Interactive visualization tools are included to facilitate downstream interpretation of cross-domain interaction networks. License: MIT + file LICENSE URL: https://github.com/BushnaqSafa/MiCARA BugReports: https://github.com/BushnaqSafa/MiCARA/issues Depends: R (>= 4.5.0) Imports: ANCOMBC, Hmisc, htmlwidgets, mice, networkD3, phyloseq, stats, utils Suggests: knitr, microbiome, rmarkdown, testthat (>= 3.0.0), webshot, webshot2 VignetteBuilder: knitr biocViews: Microbiome, DifferentialExpression, Software, Metagenomics, NetworkInference, Pathways, Network, Preprocessing, QualityControl Config/roxygen2/version: 8.1.0 Config/testthat/edition: 3 Encoding: UTF-8 Roxygen: list(markdown = TRUE) Config/pak/sysreqs: cmake libglpk-dev make libgsl0-dev libicu-dev libuv1-dev libxml2-dev libssl-dev libx11-dev zlib1g-dev Repository: https://biocstaging.r-universe.dev Date/Publication: 2026-09-06 17:51:09 UTC RemoteUrl: https://github.com/BiocStaging/MiCARA RemoteRef: HEAD RemoteSha: efe9bb0dda7cd1be02bf6b8f11eecfbb3a919c88 NeedsCompilation: no Packaged: 2026-10-04 14:42:08 UTC; root Author: Safa Bushnaq [aut, cre] (ORCID: ) Maintainer: Safa Bushnaq <19397747@brookes.ac.uk>