MultiOmicsCancer

An R package for integrative multi-omics analysis in cancer research, with a novel Immune Methylation Score (IMS) framework and built-in validation tools.

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Key Features

Standard analyses

• Differential methylation (limma)
• Differential expression (DESeq2)
• Multi-omics integration
• Survival analysis (KM + Cox)
• Visualization

Novel Q1-level tools

• build_ims() — Construct an Immune Methylation Score
• bootstrap_validate_ims() — Nested bootstrap validation
• compare_ims_clinical() — Compare IMS with clinical variables
• estimate_purity() — ESTIMATE tumor purity and immune score
• validate_proteins() — Protein-level validation via UniProt

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Installation

if (!requireNamespace("remotes", quietly = TRUE)) install.packages("remotes")
remotes::install_github("maryam6770/MultiOmicsCancer")