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  "Title": "Design-Aware Region and Block Detection for Cross-Array\nLongitudinal EWAS",
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  "Authors@R": "c(\nperson(\"Katarzyna\", \"Kamieniecka\", role = c(\"aut\", \"cre\"),\nemail = \"kkamieni@bradford.ac.uk\",\ncomment = c(ORCID = \"0009-0004-2454-5950\")),\nperson(\"Samantha\", \"McLean\", role = \"aut\",\nemail = \"S.L.Mclean@bradford.ac.uk\",\ncomment = c(ORCID = \"0000-0001-9328-8928\")),\nperson(\"Krzysztof\", \"Poterlowicz\", role = \"aut\",\nemail = \"K.Poterlowicz1@bradford.ac.uk\",\ncomment = c(ORCID = \"0000-0001-6173-5674\")))",
  "Description": "Estimation and region-calling routines for epigenome-wide\nassociation studies that combine Illumina HumanMethylation450\nand MethylationEPIC samples and follow subjects over more than\none visit. Probe-level effects are fitted within subject, so\nsubject identity, array type and chip are absorbed rather than\nmodelled; adjacent probes are grouped by within-subject\nco-methylation; regions are obtained by total-variation\ndenoising with a distance-decaying penalty, which places\nboundaries where the effect track jumps instead of thresholding\na smooth curve; and long-range blocks are called from a\nthree-state hidden semi-Markov model whose transition\nprobabilities decay with genomic distance. Selection stability\nand permutation nulls resample subjects, not samples, so a\nsubject's visit series is never split.",
  "License": "MIT + file LICENSE",
  "Encoding": "UTF-8",
  "VignetteBuilder": "knitr",
  "biocViews": "DNAMethylation, DifferentialMethylation, Epigenetics,\nMethylationArray, Regression, Software",
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  "URL": "https://github.com/kkamieniecka/ewas-crossarray-harmonise",
  "BugReports": "https://github.com/kkamieniecka/ewas-crossarray-harmonise/issues",
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      "title": "Region or block calls as a GRanges",
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