{ "_id": "6adda4069c8ebd685a2a6b99", "Package": "splitTypeR", "Type": "Package", "Version": "0.99.9", "Date": "2026-10-24", "Title": "Transcriptomic Classification using Mixture of Normal\nDistributions", "Description": "The splitTypeR package enables the classification of bulk\ntranscriptomic samples using gene signature lists. For each\nsignature, an enrichment score is first calculated for every\nsample with Bioconductor GSVA, and the uncertainty around each\nscore is estimated through permutations of the samples. Values\ndrawn from the sample-specific normal distributions are then\npooled to fit a mixture of two normal distributions that\nrepresents the whole cohort. Each sample is finally tested\nagainst the distribution with the lower mean, and samples with\na significantly higher score are assigned to the signature.\nPublished gene signatures related to pancreatic ductal\nadenocarcinoma subtyping are also provided.", "Authors@R": "c(person(\"Astrid\", \"Deschênes\", email = \"adeschen@hotmail.com\",\nrole=c(\"aut\", \"cre\"), comment=c(ORCID = \"0000-0001-7846-6749\")),\nperson(\"Pascal\", \"Belleau\", email = \"pascal_belleau@hotmail.com\",\nrole=c(\"aut\"), comment = c(ORCID = \"0000-0002-0802-1071\")),\nperson(c(\"David\", \"A.\"), \"Tuveson\", email = \"dtuveson@cshl.edu\",\nrole=c(\"aut\"), comment = c(ORCID = \"0000-0002-8017-2712\")),\nperson(\"Lustgarten Foundation\", role = \"fnd\"))", "Encoding": "UTF-8", "License": "Artistic-2.0", "biocViews": "BiologicalQuestion, Classification, GeneSetEnrichment,\nSoftware", "VignetteBuilder": "knitr", "URL": "https://github.com/adeschen/splitTypeR", "BugReports": "https://github.com/adeschen/splitTypeR/issues", "Config/roxygen2/version": "8.1.0", "Config/testthat/edition": "3", "Config/pak/sysreqs": "cmake make libmagick++-dev gsfonts libicu-dev\nlibpng-dev libuv1-dev libxml2-dev libssl-dev zlib1g-dev", "Repository": "https://biocstaging.r-universe.dev", "Date/Publication": "2026-10-25 03:45:21 UTC", "RemoteUrl": "https://github.com/BiocStaging/splitTypeR", "RemoteRef": "HEAD", "RemoteSha": "f19ea104fd7c0c822734497a6d723d10007e4d92", "NeedsCompilation": "no", "Packaged": { "Date": "2026-10-25 06:26:56 UTC", "User": "root" }, "Author": "Astrid Deschênes [aut, cre] (ORCID:\n),\nPascal Belleau [aut] (ORCID: ),\nDavid A. 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