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# CITATION.cff file created with {cffr} R package
# See also: https://docs.ropensci.org/cffr/
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cff-version: 1.2.0
message: 'To cite package "cpgdirection" in publications use:'
type: software
license: MIT
title: 'cpgdirection: Predict the Direction of CpG-Gene Expression Associations'
version: 2.99.5
doi: 10.32614/CRAN.package.cpgdirection
abstract: 'Assigns a direction to the association between DNA methylation at a CpG
  site and the expression of a nearby gene, for CpGs that have no measured expression
  quantitative trait methylation (eQTM) record. Predictions come from a precomputed
  table of 3,105,697 CpG-gene pairs covering 761,445 CpGs, assembled from four sources
  of evidence: directly measured eQTMs, summary-data Mendelian randomisation using
  genetic instruments, gradient-boosted models of genomic context and local catalogue
  structure fitted separately in blood, nasal epithelium and solid tissue, and a distance
  prior. Each call returns a direction, a calibrated probability, an evidence tier
  and an expected accuracy, and abstains where the evidence is insufficient. Predictions
  estimate direction conditional on the CpG being an eQTM; they do not establish that
  an effect exists.'
authors:
- family-names: Ein-Dor
  given-names: Tsachi
  email: teindor@runi.ac.il
  orcid: https://orcid.org/0000-0002-3078-7591
repository: https://biocstaging.r-universe.dev
repository-code: https://github.com/teindor/cpgdirection
commit: 3e1d93c7a91503cf949dbd3fac28c60f474b2900
url: https://doi.org/10.17605/OSF.IO/U3VFK
date-released: '2026-09-02'
contact:
- family-names: Ein-Dor
  given-names: Tsachi
  email: teindor@runi.ac.il
  orcid: https://orcid.org/0000-0002-3078-7591