Changes in version 0.99.0 - Initial Bioconductor package implementation. - Added controlled drug-gene relationship construction from PharmGKB, DGIdb, DrugCentral, and canonical user tables. - Added automatic public retrieval of the current ClinPGx/PharmGKB summaryAnnotations.zip archive. - Added gene-feature mapping for gene bodies, transcript promoters, coding exons, UTRs, and introns. - Added coordinate-preserving region annotation and grouped summaries. - Exact-variant annotations require explicit variant coordinates; gene and promoter overlap never imply a functional pharmacogenomic allele.