Package: fuzzyCell Type: Package Title: Bootstrap Classification Confidence for Spatial Cell-Type Analysis Version: 0.99.1 Authors@R: c( person("Shreya", "Rao", email = "shreya.rajeshrao@sydney.edu.au", role = c("aut", "cre"), comment = c(ORCID = "0009-0007-8140-6844")), person("Ellis", "Patrick", role = c("aut", "ths"))) Description: Cell type labels in spatial single-cell data are uncertain, particularly between closely related subtypes. fuzzyCell estimates a per-cell classification confidence by bootstrapping (multinomial resampling of each cell's counts followed by re-classification) and uses the resulting confidences as soft cell type weights. The weights are propagated through downstream analyses: cell type proportions, co-localisation (spicyR's L-function, and Statial's Kontextual test for relative co-localisation) and niche identification (lisaClust), each compared to the same analysis using hard labels. Cell types are organised with a user-supplied hierarchy of lineages, groups and subtypes. Helpers for testing against sample-level outcomes and for plotting are included. License: GPL (>= 3) URL: https://github.com/shreyarajeshrao/fuzzyCell BugReports: https://github.com/shreyarajeshrao/fuzzyCell/issues Encoding: UTF-8 Roxygen: list(markdown = TRUE) biocViews: Software, Spatial, SingleCell, Classification, Clustering, StatisticalMethod, Regression, SupportVectorMachine Depends: R (>= 4.5.0) Imports: BiocGenerics, BiocParallel, callr, dplyr, e1071, forcats, ggplot2, glmnet, irlba, lisaClust (>= 1.21.9), MASS, Matrix, methods, pheatmap, randomForest, RhpcBLASctl, rlang, SpatialExperiment, spicyR (>= 1.99.32), stats, SummarizedExperiment, tibble, tidyr, utils, withr Suggests: gdtools, ggalluvial, ggiraph, ggnewscale, knitr, quarto, S4Vectors, SpatialDatasets, testthat (>= 3.0.0) VignetteBuilder: quarto SystemRequirements: quarto Config/testthat/edition: 3 Config/roxygen2/version: 8.1.0 Config/pak/sysreqs: libmagick++-dev gsfonts libicu-dev libssl-dev zlib1g-dev Repository: https://biocstaging.r-universe.dev Date/Publication: 2026-10-29 02:36:37 UTC RemoteUrl: https://github.com/BiocStaging/fuzzyCell RemoteRef: HEAD RemoteSha: d171b9a457af9869138d4f998c8d3cec0fd8e6ea NeedsCompilation: no Packaged: 2026-10-29 10:24:35 UTC; root Author: Shreya Rao [aut, cre] (ORCID: ), Ellis Patrick [aut, ths] Maintainer: Shreya Rao