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# CITATION.cff file created with {cffr} R package
# See also: https://docs.ropensci.org/cffr/
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cff-version: 1.2.0
message: 'To cite package "miREA" in publications use:'
type: software
license: Artistic-2.0
title: 'miREA: Network-Based Edge-Centric MicroRNA-Oriented Enrichment Analysis'
version: 0.99.2
doi: 10.64898/2026.02.27.708509
identifiers:
- type: doi
  value: 10.32614/CRAN.package.miREA
abstract: miREA performs microRNA-oriented enrichment analysis by modeling miRNA-gene
  interaction (MGI) networks directly, rather than collapsing them to miRNA- or gene-level
  sets. It implements four node-based methods and five edge-based methods spanning
  over-representation, scoring-based, topology-aware, and network-propagation approaches,
  using expression-informed MGI edge scores to characterize regulatory strength. The
  package also provides heatmap, Sankey, and summary visualizations to explore miRNA-gene-pathway
  regulatory mechanisms discovered by the enrichment results.
authors:
- family-names: Zhang
  given-names: Zhesi
  email: zhesizhang07@gmail.com
  orcid: https://orcid.org/0009-0006-9869-9455
- family-names: Lai
  given-names: Xin
  orcid: https://orcid.org/0000-0003-4913-5822
preferred-citation:
  type: article
  title: 'miREA: a network-based tool for microRNA-oriented enrichment analysis'
  authors:
  - family-names: Zhang
    given-names: Zhesi
    email: zhesizhang07@gmail.com
    orcid: https://orcid.org/0009-0006-9869-9455
  - family-names: Lai
    given-names: Xin
    orcid: https://orcid.org/0000-0003-4913-5822
  journal: bioRxiv
  year: '2026'
  doi: 10.64898/2026.02.27.708509
repository: https://biocstaging.r-universe.dev
repository-code: https://github.com/laixn/miREA
commit: 04147f83822ac5d6acb9ae7f559500f319ba0e3e
url: https://github.com/laixn/miREA
date-released: '2026-10-16'
contact:
- family-names: Zhang
  given-names: Zhesi
  email: zhesizhang07@gmail.com
  orcid: https://orcid.org/0009-0006-9869-9455