Package: perturbMatchData 0.99.0

perturbMatchData: Reference Perturbation Signatures from GEO RNA-seq Experiments

Provides the reference perturbation expression signatures used by the perturbMatch package, which ranks the single-gene perturbations whose expression response most resembles a query signature. Each reference signature summarises the differential expression observed after a single-gene perturbation (knockdown, knockout or overexpression) in a human RNA-seq experiment deposited in the Gene Expression Omnibus. Signatures are summarised either by the characteristic direction method or by limma, each with and without surrogate variable analysis batch correction, giving four datasets served as HDF5-backed SummarizedExperiment objects.

Authors:Jamie Soul [aut, cre], Versus Arthritis [fnd]