Package: postexportKinetics 0.99.0

postexportKinetics: Kinetic Model Comparison for Post-Export RNA Conversion

Compartment-resolved four-state kinetic modelling of nuclear and cytoplasmic, unprocessed and processed RNA. Implements a constrained nested-model comparison between a null model without a post-export conversion rate and a full model with a non-negative post-export conversion rate, using trapezoidal interval balances, propagated and regularised measurement covariance, whitened non-negative least squares and a replicate-level generative bootstrap with an add-one p-value. Also provides simulation with the manuscript simulator and assay-noise models, diagnostic comparison of sampling designs with the manuscript benchmark, multiple-testing adjustment, exploratory candidate ranking, tidy result tables and plots. The post-export conversion rate is a phenomenological parameter and does not identify a specific molecular mechanism.

Authors:Luca Faretra [aut], Francesco Napolitano [aut], Massimo Pancione [aut], Luigi Cerulo [aut, cre]